Combined Effect of NF-κB Inhibitor and β2-Adrenoreceptor Agonist on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis

Bull Exp Biol Med. 2018 Aug;165(4):445-448. doi: 10.1007/s10517-018-4190-y. Epub 2018 Aug 18.

Abstract

Experiments on random-bred albino mice showed that NF-κB inhibitor (BAY 11-7082) and β2-adrenoreceptor agonist (dexmedetomidine hydrochloride) significantly reduced mouse mortality in 4 and 24 h after sepsis modeling (intraperitoneal administration of E. coli) by reducing blood levels of proinflammatory cytokines TNFα, IL-1β, and IL-6. The combined administration of NF-κB inhibitor and β2-adrenoreceptors agonist have an additive effect.

Keywords: NF-κB inhibitor; agonist of β2-adrenoreceptors; cholinergic anti-inflammatory pathway; proinflammatory cytokines; sepsis.

MeSH terms

  • Adrenergic beta-Agonists / therapeutic use*
  • Animals
  • Cytokines / metabolism*
  • Dexmedetomidine / therapeutic use*
  • Female
  • Male
  • Mice
  • NF-kappa B / antagonists & inhibitors*
  • Nitriles / therapeutic use*
  • Sepsis / drug therapy*
  • Sepsis / metabolism
  • Sepsis / mortality
  • Signal Transduction / drug effects
  • Sulfones / therapeutic use*

Substances

  • 3-(4-methylphenylsulfonyl)-2-propenenitrile
  • Adrenergic beta-Agonists
  • Cytokines
  • NF-kappa B
  • Nitriles
  • Sulfones
  • Dexmedetomidine