RETRACTED: MicroRNA-494 inhibition alleviates acute lung injury through Nrf2 signaling pathway via NQO1 in sepsis-associated acute respiratory distress syndrome

Life Sci. 2018 Oct 1:210:1-8. doi: 10.1016/j.lfs.2018.08.037. Epub 2018 Aug 17.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figures 5G,H+I, which appear to have a similar phenotype as many other publications, as detailed here: https://pubpeer.com/publications/7C9483B2551952AD53CCFCE206C4EB; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. The journal requested that the corresponding author comment on these concerns and provide the raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Acute lung injury; MicroRNA-494; NAD(P)H:quinone oxidoreductase 1; Nuclear factor E2 p45-related factor 2; Sepsis-associated acute respiratory distress syndrome.

Publication types

  • Retracted Publication

MeSH terms

  • Acute Lung Injury / etiology
  • Acute Lung Injury / genetics
  • Acute Lung Injury / prevention & control*
  • Animals
  • Disease Models, Animal*
  • Male
  • MicroRNAs / genetics*
  • NAD(P)H Dehydrogenase (Quinone) / genetics
  • NAD(P)H Dehydrogenase (Quinone) / metabolism*
  • NF-E2-Related Factor 2 / genetics
  • NF-E2-Related Factor 2 / metabolism*
  • Oxidative Stress
  • Rats
  • Rats, Sprague-Dawley
  • Respiratory Distress Syndrome / etiology
  • Respiratory Distress Syndrome / metabolism
  • Respiratory Distress Syndrome / pathology*
  • Sepsis / complications*
  • Signal Transduction
  • Up-Regulation

Substances

  • MIRN494 microRNA, rat
  • MicroRNAs
  • NF-E2-Related Factor 2
  • Nfe2l2 protein, rat
  • NAD(P)H Dehydrogenase (Quinone)
  • NQO1 protein, rat