Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Oct 30;280:9-14.
doi: 10.1016/j.pscychresns.2018.08.002. Epub 2018 Aug 3.

Impact of Substance Use Disorder on Gray Matter Volume in Schizophrenia

Affiliations
Free PMC article

Impact of Substance Use Disorder on Gray Matter Volume in Schizophrenia

Margaret Quinn et al. Psychiatry Res Neuroimaging. .
Free PMC article

Abstract

Substance use may confound the study of brain structure in schizophrenia. We used voxel-based morphometry (VBM) to examine whether differences in regional gray matter volumes exist between schizophrenia patients with (n = 92) and without (n = 66) clinically significant cannabis and/or alcohol use histories compared to 88 healthy control subjects. Relative to controls, patients with schizophrenia had reduced gray matter volume in the bilateral precentral gyrus, right medial frontal cortex, right visual cortex, right occipital pole, right thalamus, bilateral amygdala, and bilateral cerebellum regardless of substance use history. Within these regions, we found no volume differences between patients with schizophrenia and a history of cannabis and/or alcohol compared to patients with schizophrenia without a clinically significant substance use history. Our data support the idea that a clinically meaningful history of alcohol or cannabis use does not significantly compound the gray matter deficits associated with schizophrenia.

Keywords: Alcohol; Cannabis; Psychosis; Substance use disorders; Voxel-based morphometry.

Figures

Fig. 1.
Fig. 1.
Reduced gray matter volume in schizophrenia spectrum patients compared to healthy controls. Statistical results thresholded at voxelwise p < 0.001, cluster size k = 418 for cluster FDR < 0.05. Slice labels indicate MNI coordinates.
Fig. 2.
Fig. 2.
In a voxelwise analysis within the regions previously identified to differ between healthy controls (HC) and all schizophrenia spectrum patients, no significant differences in mean gray matter volume were found between schizophrenia spectrum patients with (SZ+SUD) and without (SZ-SUD) substance use histories (p > 0.05). For display purposes, bars represent age-adjusted mean gray matter volumes extracted from 14 clusters identified in the first analysis of all schizophrenia patients compared to healthy controls. Error bars indicate standard error of the mean.

Similar articles

See all similar articles

Cited by 1 article

Publication types

MeSH terms

Feedback