Gamma Oscillations in Cognitive Disorders

Curr Opin Neurobiol. 2018 Oct;52:182-187. doi: 10.1016/j.conb.2018.07.009. Epub 2018 Aug 16.


Gamma oscillations (∼25-100 Hz) are believed to play a role in cognition. Accordingly, aberrant gamma oscillations have been observed in several cognitive disorders, including Alzheimer's disease and Fragile X syndrome. Here, we review how recent results showing abnormal gamma rhythms in Alzheimer's disease and Fragile X syndrome help reveal links between cellular disturbances and cognitive impairments. We also discuss how gamma results from rodent models of Alzheimer's disease and Fragile X syndrome may provide insights about unique functions of distinct slow (∼25-50 Hz) and fast gamma (∼55-100 Hz) subtypes. Finally, we consider studies employing brain stimulation paradigms in Alzheimer's disease and discuss how such studies may reveal causal relationships between gamma impairments and memory disturbances.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alzheimer Disease / physiopathology*
  • Alzheimer Disease / therapy
  • Animals
  • Brain / physiopathology*
  • Cognition Disorders / physiopathology*
  • Cognition Disorders / therapy
  • Deep Brain Stimulation*
  • Fragile X Syndrome / physiopathology*
  • Fragile X Syndrome / therapy
  • Gamma Rhythm / physiology*
  • Humans
  • Memory Disorders / physiopathology*
  • Memory Disorders / therapy