Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing

Nutr Res. 2018 Sep:57:97-108. doi: 10.1016/j.nutres.2018.06.001. Epub 2018 Jun 9.


Aging is a multifactorial and natural process that causes physiological changes in organs, tissues and cells over time. In the skin and cartilage, aging leads to a decrease in the synthesis and changes in the arrangement of proteoglycans and collagen, in addition to the loss of glycosaminoglycans, which are responsible for the integrity and health of these tissues. We hypothesized that daily oral supplementation with a liquid nutraceutical containing hydrolyzed fish collagen, vitamins, antioxidants and other active ingredients could improve skin texture and elasticity, and in addition have a protective effect on joint health. A double-blind, randomized, placebo-controlled clinical trial was conducted on 120 subjects who consumed either the test product or placebo on a daily basis for 90 days. Subjects consuming the test product had an overall significant increase in skin elasticity (+40%; P < .0001) when compared to placebo. Histological analysis of skin biopsies revealed positive changes in the skin architecture, with a reduction in solar elastosis and improvement in collagen fiber organization in the test product group. As reported in the self-perception questionnaires, these results were confirmed by the subjects' own perceptions in that participants agreed their skin was more hydrated and more elastic. In addition, the consumption of the test product reduced joint pain by -43% and improved joint mobility by +39%. Oral supplementation with collagen bioactive peptides combined with chondroitin sulphate, glucosamine, L-carnitine, vitamins, and minerals significantly improved the clinical parameters related to skin aging and joint health, and therefore, might be an effective solution to slow down the hallmarks of aging.

Keywords: Antioxidants; Hydrolyzed collagen; Joint pain; Nutraceuticals; Skin aging; Skin elasticity.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Antioxidants / pharmacology*
  • Collagen / chemistry*
  • Dietary Supplements*
  • Double-Blind Method
  • Elasticity
  • Female
  • Fish Proteins / pharmacology
  • Humans
  • Joints / drug effects*
  • Male
  • Middle Aged
  • Peptides / pharmacology*
  • Protein Hydrolysates / pharmacology
  • Skin / drug effects*
  • Skin Aging / drug effects
  • Vitamins / pharmacology*


  • Antioxidants
  • Fish Proteins
  • Peptides
  • Protein Hydrolysates
  • Vitamins
  • Collagen