Correlations between T-cell specificity and the structure of the antigen receptor

Nature. 1986 May 15-21;321(6067):219-26. doi: 10.1038/321219a0.

Abstract

The derived amino-acid sequences of the heterodimeric antigen receptors expressed by a series of murine T-cell clones are presented. A comparison of the receptor sequences indicates that several mechanisms for generating receptor diversity can influence T-cell specificity, including junctional diversity, combinatorial joining, and combinatorial chain associations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Clone Cells / immunology
  • Columbidae
  • Cytochrome c Group / immunology
  • DNA / genetics
  • Genes, MHC Class II
  • Lymphocyte Activation
  • Mutation
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology*
  • Recombination, Genetic
  • T-Lymphocytes / immunology*

Substances

  • Cytochrome c Group
  • Receptors, Antigen, T-Cell
  • DNA

Associated data

  • GENBANK/X03858
  • GENBANK/X03859
  • GENBANK/X03860
  • GENBANK/X03861
  • GENBANK/X03862
  • GENBANK/X03863
  • GENBANK/X03864
  • GENBANK/X03865