Is the cancer survival improvement in European and American adolescent and young adults still lagging behind that in children?

Pediatr Blood Cancer. 2019 Jan;66(1):e27407. doi: 10.1002/pbc.27407. Epub 2018 Aug 19.


Improvements during 1978 to 2006 in the 5-year survival rate of adolescents and young adults (AYAs, age 15-39) and children with cancers common to both age groups were evaluated for 1978 to 2006 in Europe and the USA. AYAs had absolute survival increases of 25% and 15% in Europe and the USA, respectively, but in both cases, AYA 5-year survival was, as of 2006, 4% lower than those in children. Acute lymphoblastic leukemia (ALL) explained most of the survival difference between AYAs and children on both the continents. In the USA, 20- to 39-year-olds with ALL have had less survival improvement than those in Europe.

Keywords: acute lymphoblastic leukemia; adolescents and young adults; cancer; children; survival; time trends.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Child
  • Europe / epidemiology
  • Humans
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Prognosis
  • Survival Rate
  • United States / epidemiology
  • Young Adult