Top-down control: A unified principle of cortical learning

Abstract

Cognitive control of the brain flexibly maps incoming sensory information onto execution of actions appropriate for the current goal. Learning is a process that enables the brain to estimate current states of the world by extracting its spatiotemporal structure and generate goal-directed motor outputs through selective association of events or movement refinement. Accumulating evidence suggests that top-down control from higher-order brain areas modulates downstream neural activity and changes local computations that are critical for the execution of learned behavior. Recent technological advances in multi-site recordings and optogenetic approaches are beginning to reveal more direct evidence of top-down cognitive control by monitoring and perturbing activity of top-down inputs and observing its causal consequences on behavior and downstream neural dynamics. Here I highlight that learning-related changes in neural circuits in distinct domains of learning converge onto a unified principle; namely recruitment of top-down control whether it involves sensory, motor or offline learning. Recruitment of top-down control may reflect experience-dependent adaptation and integration of internal models for refined state estimation and goal-directed optimal behavior.

Keywords: Motor learning; Offline learning; Perceptual learning; Top-down control.