Plane warts under spontaneous regression. Immunopathologic study on cellular constituents leading to the inflammatory reaction

Arch Dermatol. 1986 Jun;122(6):655-9. doi: 10.1001/archderm.122.6.655.


Immunohistologically, cellular infiltrates in regressing plane warts were mainly composed of lymphocytes and mononuclear phagocytes. There were many infiltrating T lymphocytes. Immunoelectron microscopic observation demonstrated that both helper/inducer and suppressor/cytotoxic phenotypes of T lymphocytes infiltrated in the lesions. OKT6-positive cells were observed in the dermis as well as in the epidermis. Moreover, as noted in allergic contact dermatitis, the apposition of T lymphocytes to Langerhans' cell-like cells could be seen. Lymphocytes and a small number of mononuclear phagocytes were found adjacent to damaged keratinocytes in the epidermis, the picture of which has been described as satellite cell necrosis, a hallmark of cytotoxic reaction by aggressors. These findings suggest that specific cell-mediated immunity against virus-infected keratinocytes takes place in the process of regressing plane warts.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Monoclonal / immunology
  • Female
  • Humans
  • Immunity, Cellular
  • Immunoenzyme Techniques
  • Inflammation / immunology
  • Langerhans Cells / immunology
  • Male
  • Microscopy, Electron
  • Papillomaviridae / immunology
  • Phagocytes / immunology
  • Remission, Spontaneous
  • Skin / immunology
  • Skin Diseases / immunology*
  • Skin Diseases / pathology
  • T-Lymphocytes / classification
  • T-Lymphocytes / immunology
  • Tumor Virus Infections / immunology
  • Warts / immunology*
  • Warts / pathology


  • Antibodies, Monoclonal