Ki-67: More Hidden behind a 'Classic Proliferation Marker'

Trends Biochem Sci. 2018 Oct;43(10):747-748. doi: 10.1016/j.tibs.2018.08.004. Epub 2018 Aug 18.

Abstract

Nuclear antigen Ki-67 is widely accepted as a cell proliferation marker in both research and cancer diagnostic settings. Despite its extensive use and clinical value, very little is still known about the biological function of Ki-67. A recent work published in Cell Reports has revealed important novel aspects of Ki-67 regulation that could provide new and extended prognostic and therapeutic value.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Proliferation*
  • Ki-67 Antigen*
  • Prognosis

Substances

  • Ki-67 Antigen