The early region of human papovavirus JC induces dysmyelination in transgenic mice

Cell. 1986 Jul 4;46(1):13-8. doi: 10.1016/0092-8674(86)90855-x.


Transgenic mice containing the early region of human papovavirus JC were produced. Some of these mice exhibited a shaking disorder similar to the previously described mutant mice jimpy or quaking. Neuropathological analysis indicated a dysmyelination in the central nervous system, but not the peripheral nervous system. A high level of JCV T-antigen mRNA was present in the brains of the mice exhibiting the myelin disorder. JC virus is associated in humans with a degenerative demyelinating disease: progressive multifocal leukoencephalopathy. The JCV-containing transgenic mice may therefore provide an animal model for studying this disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antigens, Viral, Tumor / analysis
  • Antigens, Viral, Tumor / genetics
  • Demyelinating Diseases / microbiology*
  • Genes, Viral
  • JC Virus / genetics
  • JC Virus / immunology
  • JC Virus / pathogenicity*
  • Mice
  • Neoplasms, Experimental / genetics
  • Pedigree
  • Polyomavirus / pathogenicity*
  • RNA, Messenger / analysis
  • RNA, Viral / analysis
  • Transfection


  • Antigens, Viral, Tumor
  • RNA, Messenger
  • RNA, Viral