[The use of immunomodulators, antioxidants and hepatoprotectors for the correction of the liver, erythrocites and the immune system disorders in chronic ethanol intoxication]

Biomed Khim. 2018 Aug;64(4):360-367. doi: 10.18097/PBMC20186404360.
[Article in Russian]

Abstract

The effectiveness of three various combinations of an immunomodulator with an antioxidant and a membrane protector in the correction of metabolic and immune disorders has been studied in the experiment under 60-days ethanol intoxication. The development of such biochemical syndromes of the liver damage as cytolysis, intrahepatic, intracellular cholestasis, toxic liver damage by necrotic type, insufficiency of synthetic processes and inflammatory has been revealed. Oxidative stress development and the activation of lipid peroxidation on the systemic (blood plasma) and local level (erythrocytes) have been established. Suppression of adaptive immunity formation and phagocytic capabilities of neutrophils under the increase in their oxygen-dependent activity has been determined, which indicates the presence and possible progression of the inflammatory process at the systemic level. A disorder of erythrocytes metabolic activity, a decrease in stable metabolites of nitric oxide detected in blood plasma been revealed, indicating its uncompensated consumption, causing vasoconstriction and thrombosis, which can additionally arise due to the established increase in the prothrombin index. Combined use of "Longidasa", "Mexicor", "Essentiale forte N" or "Glutoxim", "Mexidol", "Heptral" was more effective in the correction of immune-metabolic disorders in chronic alcohol intoxication than "Hepon", "Hypoxen" and "Phosphogliv".

Pri 60-dnevnoĭ intoksikatsii étanolom v éksperimente izuchena éffektivnost' trekh razlichnykh sochetaniĭ immunomoduliatora s antioksidantom i membranoprotektorom v korrektsii metabolicheskikh i immunnykh narusheniĭ. Vyiavleno razvitie biokhimicheskikh sindromov porazheniia pecheni: tsitoliticheskogo, vnutripechenochnogo, vnutrikletochnogo kholestaza, toksicheskogo porazheniia pecheni po nekroticheskomu tipu, nedostatochnosti sinteticheskikh protsessov i vospalitel'nogo. Ustanovleno razvitie oksidantnogo stressa i aktivatsiia perekisnogo okisleniia lipidov na sistemnom (plazma krovi) i lokal'nom urovne (éritrotsity). Opredelena supressiia formirovaniia adaptivnogo immuniteta i fagotsitarnykh vozmozhnosteĭ neĭtrofilov pri povyshenii ikh kislorodzavisimoĭ aktivnosti, chto svidetel'stvuet o nalichii i vozmozhnom progressirovanii vospalitel'nogo protsessa na sistemnom urovne. Vyiavleno narushenie metabolicheskoĭ aktivnosti éritrotsitov, snizhenie v plazme krovi stabil'nykh metabolitov oksida azota, chto govorit o nekompensirovannom ego raskhode, vyzyvaiushchem vazokonstriktsiiu i tromboz, kotorye mogut dopolnitel'no voznikat' vsledstvie ustanovlennogo povysheniia protrombinovogo indeksa. Primenenie sochetaniĭ “Longidaza”, “Meksikor”, “Éssentsiale forte N” ili “Glutoksim”, “Meksidol”, “Geptral” okazalos' bolee éffektivnym v korrektsii immunometabolicheskikh narusheniĭ pri khronicheskoĭ alkogol'noĭ intoksikatsii, chem “Gepon”, “Gipoksen” i “Fosfogliv”.

Keywords: ethanol; intoxication; metabolic disorders; pharmacological correction.

MeSH terms

  • Alcoholism / blood
  • Alcoholism / drug therapy*
  • Alcoholism / immunology
  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / therapeutic use*
  • Disease Models, Animal
  • Drug Therapy, Combination
  • Erythrocytes / drug effects*
  • Erythrocytes / metabolism
  • Hypolipidemic Agents / administration & dosage
  • Hypolipidemic Agents / therapeutic use*
  • Immune System / drug effects*
  • Immunologic Factors / administration & dosage
  • Immunologic Factors / therapeutic use*
  • Lipid Peroxidation / drug effects
  • Lipid Peroxidation / immunology
  • Liver / drug effects*
  • Liver / metabolism
  • Liver Function Tests
  • Male
  • Nitric Oxide / blood
  • Oxidative Stress / drug effects
  • Oxidative Stress / immunology
  • Rats, Wistar

Substances

  • Antioxidants
  • Hypolipidemic Agents
  • Immunologic Factors
  • Nitric Oxide