Soft tissue sarcomas (STS) are a group of more than 60 different neoplasms that can originate from any location throughout the human body and affect individuals at the extremes of age. From skeletal muscle, adipose tissue, blood, and lymphatics to connective tissue and peripheral nerves, these neoplasms can span a range of clinical presentations from benign lipomas to aggressive metastatic angiosarcomas. The real challenge in diagnosing these conditions is that several non-neoplastic conditions mimic STS. Soft tissue sarcomas are separated categorically as trunk and extremity from retroperitoneum. The majority of STS occurs spontaneously. However, germline mutations, radiation, and environmental exposure(s) have been causative.
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