Clindamycin is an FDA-approved for the treatment of septicemia, intra-abdominal infections, lower respiratory infections, gynecological infections, bone, and joint infections, and skin and skin structure infections. Clindamycin is also used in the treatment of streptococcal pharyngitis, acne vulgaris, bacterial vaginosis, and severe pelvic inflammatory disease. Although not a first-line treatment, Infectious Diseases Society of America (IDSA) has published guidelines for using intravenous (IV) clindamycin for the inpatient treatment of community-acquired pneumonia and aspiration pneumonia. Dentists will use clindamycin for prophylactic coverage against endocarditis. Anesthesiologists and surgeons will often administer clindamycin per American Society of Health-System Pharmacists (ASHP) and IDSA guidelines as prophylaxis in the operating room. Gynecologists use clindamycin in combination with gentamycin +/- ampicillin for covering their patients with endometritis. It can also be an alternative to metronidazole for treating Gardnerella vaginosis, which presents with gray, fishy vaginal odor with clue cells on wet prep.
Copyright © 2020, StatPearls Publishing LLC.
Treatment of bacterial vaginosis: a comparison of oral metronidazole, metronidazole vaginal gel, and clindamycin vaginal cream.J Fam Pract. 1995 Nov;41(5):443-9. J Fam Pract. 1995. PMID: 7595261 Clinical Trial.
Bacterial vaginosis: current review with indications for asymptomatic therapy.Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1210-7. doi: 10.1016/s0002-9378(12)90729-2. Am J Obstet Gynecol. 1991. PMID: 1951577 Review.
Comparison of metronidazole with clindamycin-gentamycin combination in the prevention of infectious complications after elective colonic surgery.Ann Chir Gynaecol. 1982;71(6):317-20. Ann Chir Gynaecol. 1982. PMID: 7159001 Clinical Trial.
[Bacterial vaginosis].Orv Hetil. 1998 Jun 7;139(23):1403-8. Orv Hetil. 1998. PMID: 9658870 Review. Hungarian.
The Natural Antimicrobial Subtilosin A Synergizes with Lauramide Arginine Ethyl Ester (LAE), ε-Poly-L-lysine (Polylysine), Clindamycin Phosphate and Metronidazole, Against the Vaginal Pathogen Gardnerella vaginalis.Probiotics Antimicrob Proteins. 2015 Jun;7(2):164-71. doi: 10.1007/s12602-014-9183-1. Probiotics Antimicrob Proteins. 2015. PMID: 25588687