Cancer of the gastroesophageal junction: a diagnosis, classification, and management review

Ann N Y Acad Sci. 2018 Dec;1434(1):132-138. doi: 10.1111/nyas.13954. Epub 2018 Aug 23.


Management of gastroesophageal junction (GEJ) adenocarcinoma is a controversial topic. The rising incidence of this cancer requires a clear consensus to ensure proper management. Application of oncological principles for tumors of the esophagus or stomach is not possible because of comparative differences in the biology of GEJ adenocarcinoma, leading to different therapeutic options. Staging work-up with endoscopy, endosonography, and PET is essential to inform the choice of neoadjuvant treatment and surgical approach to GEJ adenocarcinoma. Surgery remains the only curative treatment and should be undertaken in specialized centers.

Keywords: FLOT; esophagectomy; minimally invasive.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma* / diagnosis
  • Adenocarcinoma* / pathology
  • Adenocarcinoma* / physiopathology
  • Adenocarcinoma* / therapy
  • Esophageal Neoplasms* / diagnosis
  • Esophageal Neoplasms* / pathology
  • Esophageal Neoplasms* / physiopathology
  • Esophageal Neoplasms* / therapy
  • Esophagogastric Junction* / pathology
  • Esophagogastric Junction* / physiopathology
  • Humans
  • Neoadjuvant Therapy / methods*

Supplementary concepts

  • Adenocarcinoma Of Esophagus