Bridging the Gap between Mechanics and Genetics in Cortical Folding: ECM as a Major Driving Force

Florence Wianny; Henry Kennedy; Colette Dehay

doi:10.1016/j.neuron.2018.08.012

Bridging the Gap between Mechanics and Genetics in Cortical Folding: ECM as a Major Driving Force

Neuron. 2018 Aug 22;99(4):625-627. doi: 10.1016/j.neuron.2018.08.012.

Authors

Florence Wianny¹, Henry Kennedy², Colette Dehay³

Affiliations

¹ Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France.
² Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France; Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences (CAS) Key Laboratory of Primate Neurobiology, CAS, Shanghai 200031, China.
³ Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France. Electronic address: colette.dehay@inserm.fr.

PMID: 30138583
DOI: 10.1016/j.neuron.2018.08.012

Abstract

Folding of the cerebral cortex results from interrelated biological and mechanical processes that are incompletely understood. In this issue, Long et al. identify the key roles of HAPLN1, lumican, collagen I, and HA in relationship with changes in tissue stiffness.

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MeSH terms

Collagen
Extracellular Matrix
Humans
Hyaluronic Acid*
Lumican
Mechanical Phenomena
Neocortex*

Substances

Lumican
Hyaluronic Acid
Collagen