Bridging the Gap between Mechanics and Genetics in Cortical Folding: ECM as a Major Driving Force

Neuron. 2018 Aug 22;99(4):625-627. doi: 10.1016/j.neuron.2018.08.012.


Folding of the cerebral cortex results from interrelated biological and mechanical processes that are incompletely understood. In this issue, Long et al. identify the key roles of HAPLN1, lumican, collagen I, and HA in relationship with changes in tissue stiffness.

Publication types

  • Comment

MeSH terms

  • Collagen
  • Extracellular Matrix
  • Humans
  • Hyaluronic Acid*
  • Lumican
  • Mechanical Phenomena
  • Neocortex*


  • Lumican
  • Hyaluronic Acid
  • Collagen