Effect of Sn(II) ion concentration and heparin on technetium-99m red blood cell labeling

J Nucl Med. 1986 Jul;27(7):1202-6.


While convenience and economy favor the use of in vivo methods for labeling red blood cells (RBCs) with [99mTc]pertechnetate, previous reports suggested that patient medication such as heparin might interfere and thus result in inferior quality images. In this study, using a canine model, the role of stannous Sn(II) ion in in vivo and in vitro labeling of RBCs both in the presence and absence of a therapeutic dose of heparin was investigated. Our results showed that Sn(II) ion concentration of 20 micrograms/kg body weight levels provided better than 80% in vivo labeling efficiency enabling high quality blood-pool images even in the presence of therapeutic doses of heparin.

MeSH terms

  • Animals
  • Dogs
  • Erythrocytes*
  • Heparin / therapeutic use*
  • In Vitro Techniques
  • Ions
  • Isotope Labeling / methods*
  • Reagent Kits, Diagnostic
  • Sodium Pertechnetate Tc 99m*
  • Tin Polyphosphates
  • Tin*


  • Ions
  • Reagent Kits, Diagnostic
  • Tin Polyphosphates
  • Tin
  • Heparin
  • Sodium Pertechnetate Tc 99m