Bifunctional Au@Bi2 Se3 Core-Shell Nanoparticle for Synergetic Therapy by SERS-Traceable AntagomiR Delivery and Photothermal Treatment

Small. 2018 Sep;14(38):e1802934. doi: 10.1002/smll.201802934. Epub 2018 Aug 23.


For the first time, topological insulator bismuth selenide nanoparticles (Bi2 Se3 NP) are core-shelled with gold (Au@Bi2 Se3 ) i) to represent considerably small-sized (11 nm) plasmonic nanoparticles, enabling accurate bioimaging in the near-infrared region; ii) to substantially improve Bi2 Se3 biocompatibility, iii) water dispersibility, and iv) surface functionalization capability through straightforward gold-thiol interaction. The Au@Bi2 Se3 is subsequently functionalized for v) effective targeting of SH-SY5Y cancer cells, vi) disrupting the endosome/lysosome membrane, vii) traceable delivery of antagomiR-152 and further synergetic oncomiR knockdown and photothermal therapy (PTT). Unprecedentedly, it is observed that the Au shell thickness has a significant impact on evoking the exotic plasmonic features of Bi2 Se3 . The Au@Bi2 Se3 possesses a high photothermal conversion efficiency (35.5%) and a remarkable surface plasmonic effect (both properties are approximately twofold higher than those of 50 nm Au nanoparticles). In contrast to the siRNA/miRNA delivery methods, the antagomiR delivery is based on strand displacement, in which the antagomiR-152 is displaced by oncomiR-152 followed by a surface-enhanced Raman spectroscopy signal drop. This enables both cancer cell diagnosis and in vitro real-time monitoring of the antagomiR release. This selective PTT nanoparticle can also efficiently target solid tumors and undergo in vivo PTT, indicating its potential clinical applications.

Keywords: SERS; gold Bi2Se3 core-shell nanoparticle; microRNA; photothermal therapy; topological insulator.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antagomirs / chemistry*
  • Bismuth
  • Gold / chemistry*
  • Metal Nanoparticles / chemistry*
  • MicroRNAs / genetics
  • Organoselenium Compounds / chemistry*
  • Phototherapy / methods*
  • RNA, Small Interfering / genetics
  • Selenium Compounds
  • Theranostic Nanomedicine / methods


  • Antagomirs
  • MicroRNAs
  • Organoselenium Compounds
  • RNA, Small Interfering
  • Selenium Compounds
  • Gold
  • bismuth selenide
  • Bismuth