Identification of gut microbiome signatures associated with longevity provides a promising modulation target for healthy aging

Gut Microbes. 2019;10(2):210-215. doi: 10.1080/19490976.2018.1494102. Epub 2018 Aug 24.


The world population is aging, which poses a significant burden to the economy and health care system. As people age, so do their gut microbiomes. Age-related changes in gut microbiome have been reported, including decreased microbial diversity and increased Proteobacteria. Recently, we characterized the gut microbiome of a group of long-living (≥ 90 years old) Chinese people. Interestingly, the diversity of their gut microbiome was greater than that of a young adult control group. We also identified several potentially beneficial bacteria enriched in the long-living Chinese group. These results were validated using data from an independent Italian cohort that included a group of long-living individuals. Other recent studies have found similar results. Here, we provide a summary of these discoveries and discuss their implications in healthy aging.

Keywords: beneficial bacteria; diversity; gut microbiota; healthy aging.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Bacteria / classification
  • Bacteria / genetics
  • Bacteria / isolation & purification
  • Biodiversity
  • China
  • Cohort Studies
  • Gastrointestinal Microbiome / physiology*
  • Healthy Aging / physiology*
  • Humans
  • Italy
  • Longevity / physiology*
  • Young Adult

Grants and funding

This work was supported by the National Natural Science Foundation of China (NSFC) to Y.L. [31471997].