Youth Comes But Once in a Lifetime for Adult-Born Neurons

Kurt A Sailor; Pierre-Marie Lledo

doi:10.1016/j.tins.2018.07.003

Youth Comes But Once in a Lifetime for Adult-Born Neurons

Trends Neurosci. 2018 Sep;41(9):563-566. doi: 10.1016/j.tins.2018.07.003.

Authors

Kurt A Sailor¹, Pierre-Marie Lledo²

Affiliations

¹ Laboratory for Perception and Memory, Pasteur Institute, F-75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 3571, F-75015 Paris, France. Electronic address: ksailor@pasteur.fr.
² Laboratory for Perception and Memory, Pasteur Institute, F-75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 3571, F-75015 Paris, France. Electronic address: pierre-marie.lledo@pasteur.fr.

PMID: 30143182
DOI: 10.1016/j.tins.2018.07.003

Abstract

Using new methods to functionally dissect circuits, two papers from 2015 found enhanced synaptic properties of the inputs and outputs of hippocampal adult-born neurons specifically during a critical period of their development. These studies provided a circuit-level view of unique roles for new neurons and how they cope with the ever-changing environment.

Keywords: critical period; enriched environment; feedback inhibition; hippocampal adult neurogenesis; plasticity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Animals
Critical Period, Psychological*
Hippocampus / cytology
Hippocampus / physiology
Humans
Neurogenesis / physiology*
Neuronal Plasticity / physiology
Neurons / physiology*