Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: A vicious cycle

doi:10.1111/jdi.12918

. 2019 Jan;10(1):29-31.

doi: 10.1111/jdi.12918. Epub 2018 Sep 24.

Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: A vicious cycle

Chi Ho Lee^{1

2}, Karen Sl Lam^{1

2

3}

Affiliations

¹ Department of Medicine, University of Hong Kong, Hong Kong, China.
² Research Center of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, China.
³ State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China.

PMID: 30144345
PMCID: PMC6319486
DOI: 10.1111/jdi.12918

Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: A vicious cycle

Chi Ho Lee et al. J Diabetes Investig. 2019 Jan.

. 2019 Jan;10(1):29-31.

doi: 10.1111/jdi.12918. Epub 2018 Sep 24.

Authors

Chi Ho Lee^{1

2}, Karen Sl Lam^{1

2

3}

Affiliations

¹ Department of Medicine, University of Hong Kong, Hong Kong, China.
² Research Center of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, China.
³ State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China.

PMID: 30144345
PMCID: PMC6319486
DOI: 10.1111/jdi.12918

No abstract available

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Figures

**Figure 1**
The relationship between adipose tissue insulin resistance and inflammation in diet‐induced obesity. ER, endoplasmic reticulum; JNK, c‐Jun NH2‐terminal kinase; NFκB, nuclear factor kappa B.

See this image and copyright information in PMC

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References

1. Weisberg SP, McCann D, Desai M, et al Obesity is associated with macrophage accumulation in adipose tissue. J Clin Investig 2003; 112: 1796–1808. - PMC - PubMed
1. Shimobayashi M, Albert V, Woelnerhanssen B, et al Insulin resistance causes inflammation in adipose tissue. J Clin Investig 2018; 128: 1538–1550. - PMC - PubMed
1. Morley TS, Xia JY, Scherer PE. Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements. Nat Commun 2015; 6: 7906. - PMC - PubMed
1. McCurdy CE, Schenk S, Holliday MJ, et al Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet‐induced obese mice. Diabetes 2012; 61: 2495–2505. - PMC - PubMed
1. Turner N, Kowalski GM, Leslie SJ, et al Distinct patterns of tissue‐specific lipid accumulation during the induction of insulin resistance in mice by high‐fat feeding. Diabetologia 2013; 56: 1638–1648. - PubMed

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[1] Weisberg SP, McCann D, Desai M, et al Obesity is associated with macrophage accumulation in adipose tissue. J Clin Investig 2003; 112: 1796–1808. - PMC - PubMed

[2] Weisberg SP, McCann D, Desai M, et al Obesity is associated with macrophage accumulation in adipose tissue. J Clin Investig 2003; 112: 1796–1808. - PMC - PubMed

[3] Shimobayashi M, Albert V, Woelnerhanssen B, et al Insulin resistance causes inflammation in adipose tissue. J Clin Investig 2018; 128: 1538–1550. - PMC - PubMed

[4] Shimobayashi M, Albert V, Woelnerhanssen B, et al Insulin resistance causes inflammation in adipose tissue. J Clin Investig 2018; 128: 1538–1550. - PMC - PubMed

[5] Morley TS, Xia JY, Scherer PE. Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements. Nat Commun 2015; 6: 7906. - PMC - PubMed

[6] Morley TS, Xia JY, Scherer PE. Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements. Nat Commun 2015; 6: 7906. - PMC - PubMed

[7] McCurdy CE, Schenk S, Holliday MJ, et al Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet‐induced obese mice. Diabetes 2012; 61: 2495–2505. - PMC - PubMed

[8] McCurdy CE, Schenk S, Holliday MJ, et al Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet‐induced obese mice. Diabetes 2012; 61: 2495–2505. - PMC - PubMed

[9] Turner N, Kowalski GM, Leslie SJ, et al Distinct patterns of tissue‐specific lipid accumulation during the induction of insulin resistance in mice by high‐fat feeding. Diabetologia 2013; 56: 1638–1648. - PubMed

[10] Turner N, Kowalski GM, Leslie SJ, et al Distinct patterns of tissue‐specific lipid accumulation during the induction of insulin resistance in mice by high‐fat feeding. Diabetologia 2013; 56: 1638–1648. - PubMed

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Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: A vicious cycle

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Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: A vicious cycle

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