New concepts in opioid analgesia

Expert Opin Investig Drugs. 2018 Oct;27(10):765-775. doi: 10.1080/13543784.2018.1516204. Epub 2018 Sep 7.

Abstract

Introduction: Opioids are the oldest and most potent drugs for the treatment of severe pain, but they are burdened by detrimental side effects such as respiratory depression, addiction, sedation, nausea, and constipation. Their clinical application is undisputed in acute (e.g. perioperative) and cancer pain, but their long-term use in chronic pain has met increasing scrutiny and has contributed to the current 'opioid crisis.'

Areas covered: This article reviews pharmacological principles and research strategies aiming at novel opioids with reduced side effects. Basic mechanisms underlying pain, opioid analgesia, and other opioid actions are outlined. To illustrate the clinical situation and medical needs, plasticity of opioid receptors, intracellular signaling pathways, endogenous and exogenous opioid receptor ligands, central and peripheral sites of analgesic, and side effects are discussed.

Expert opinion: The epidemic of opioid misuse has taught us that there is a lack of fundamental knowledge about the characteristics and management of chronic pain, that conflicts of interest and validity of models must be considered in the context of drug development, and that novel analgesics with less abuse liability are badly needed. Currently, the most promising perspectives appear to be augmenting endogenous opioid actions and selectively targeting pathological conformations of peripheral opioid receptors.

Keywords: Acidosis; G-protein coupled receptors; addiction; analgesia; biased signaling; constipation; inflammation; injury; opioid; pain; respiratory depression; sedation.

Publication types

  • Review

MeSH terms

  • Analgesics, Opioid / adverse effects
  • Analgesics, Opioid / pharmacology
  • Analgesics, Opioid / therapeutic use*
  • Animals
  • Chronic Pain / drug therapy*
  • Chronic Pain / physiopathology
  • Drug Design
  • Humans
  • Opioid-Related Disorders / epidemiology
  • Opioid-Related Disorders / prevention & control
  • Receptors, Opioid / drug effects*
  • Signal Transduction / drug effects

Substances

  • Analgesics, Opioid
  • Receptors, Opioid