Do not poison thyself: Mechanisms to avoid self-toxicity could inspire novel compounds and pathways for synthetic biology and applications for agriculture
EMBO Rep. 2018 Sep;19(9):e46756.
doi: 10.15252/embr.201846756.
Epub 2018 Aug 27.
- PMID: 30150322
- PMCID: PMC6123641
- DOI: 10.15252/embr.201846756
Abstract
The mechanisms by which poisonous plants and animals protect themselves against their own toxins provide interesting leads for synthetic biology with potential applications in medicine and agriculture.
MeSH terms
- Adaptation, Biological / physiology
- Agriculture*
- Animals
- Animals, Poisonous / genetics
- Animals, Poisonous / metabolism*
- Bridged Bicyclo Compounds, Heterocyclic / poisoning
- Crops, Agricultural / toxicity
- Genetic Markers
- Humans
- Metabolic Networks and Pathways
- Mutation
- Plant Breeding
- Plants, Genetically Modified
- Pyridines / poisoning
- Receptors, Muscarinic / chemistry
- Receptors, Nicotinic / chemistry
- Synthetic Biology*
- Toxins, Biological* / metabolism
- Toxins, Biological* / poisoning
- Toxins, Biological* / toxicity
Substances
- Bridged Bicyclo Compounds, Heterocyclic
- Genetic Markers
- Pyridines
- Receptors, Muscarinic
- Receptors, Nicotinic
- Toxins, Biological
- epibatidine