Acute Kidney Injury in a Patient on Tenofovir Alafenamide Fumarate After Initiation of Treatment for Hepatitis C Virus Infection

Open Forum Infect Dis. 2018 Jul 30;5(8):ofy189. doi: 10.1093/ofid/ofy189. eCollection 2018 Aug.


HIV treatment with tenofovir alafenamide fumarate (TAF) has decreased renal toxicity compared with tenofovir disoproxil fumarate in clinical trials. We report the case of a patient with HIV/HCV coinfection who was started on a TAF-based HIV regimen and developed acute kidney injury that worsened with the addition of sofosbuvir-ledipasvir.

Keywords: HIV infection; acute kidney injury; hepatitis C; tenofovir alafenamide.