Immune hemolysis secondary to injection of contrast medium

Transfusion. 2018 Sep;58(9):2113-2114. doi: 10.1111/trf.14786. Epub 2018 Aug 28.

Abstract

Background: Drug-induced immune hemolytic anemia (DIIHA) is a rare but sometimes severe side effect.

Case report: We describe the case of a 32-year-old patient who presented a cardiovascular collapse and a severe hemolysis secondary to the injection of iomeprol, a contrast medium, after a carcinologic surgery.

Results: The evolution was favorable after blood transfusion and short catecholamine support. The biology showed drug-dependent antibodies after incubation with iomeprol.

Conclusion: This case is the second report of DIIHA with iomeprol.

Publication types

  • Review

MeSH terms

  • Adult
  • Anemia, Hemolytic / chemically induced*
  • Anemia, Hemolytic / complications
  • Anemia, Hemolytic / immunology
  • Anemia, Hemolytic / therapy
  • Antibody Specificity
  • Catecholamines / therapeutic use
  • Combined Modality Therapy
  • Contrast Media / adverse effects*
  • Erythrocyte Transfusion
  • Female
  • Hematuria / diagnostic imaging
  • Humans
  • Iopamidol / adverse effects
  • Iopamidol / analogs & derivatives*
  • Iopamidol / immunology
  • Ovarian Neoplasms / complications
  • Ovarian Neoplasms / surgery
  • Postoperative Complications / diagnostic imaging
  • Shock / etiology*
  • Tomography, X-Ray Computed

Substances

  • Catecholamines
  • Contrast Media
  • iomeprol
  • Iopamidol