Inclusion of Fructooligosaccharide and Resistant Maltodextrin in High Fat Diets Promotes Simultaneous Improvements on Body Fat Reduction and Fecal Parameters

Molecules. 2018 Aug 28;23(9):2169. doi: 10.3390/molecules23092169.


This study investigated the effects of incorporating a mixture of fructooligosaccharide (FOS) and resistant maltodextrin (RMD) at a ratio of 1:2 on body fat accumulation and fecal bacterial parameters in rats. Our results indicated that high dietary fat consumption might effectively (p < 0.05) increase body fat, but consequently inducing a significantly (p < 0.05) higher growth of C. perfringens and retarded growth (p < 0.05) of the Bifidobacterium spp. in the large intestine. As compared with the high fat control, an incorporation of the FOS and RMD mixture at a high dose (0.97 and 1.94 g/kg body weight, respectively) could result in a significant (p < 0.05) reduction in feed efficiency (-16%), total visceral fat (-17.4%), non-visceral fat levels (-20.3%), and total body fat (-19.2%). Furthermore, feeding the FOS and RMD mixture at a high dose was capable to counter the above undesirable impacts by reducing the C. perfringens count (-14.8%) and increasing the total Bifidobacterium count (134.4%) and total fecal short chain fatty acids (195.4%). A supplementation of adequate amount of FOS and RMD might confer a concreted solution to the obesity and deteriorated fecal bacteria profiles due to high fat consumption.

Keywords: body fat; fecal bacteria; fecal parameters; fructooligosaccharide; resistant maltodextrin.

MeSH terms

  • Adiposity*
  • Animal Feed*
  • Animals
  • Body Composition
  • Body Weight
  • Diet, High-Fat*
  • Feces / chemistry*
  • Feces / microbiology*
  • Intra-Abdominal Fat / anatomy & histology
  • Lipids / chemistry
  • Male
  • Oligosaccharides*
  • Polysaccharides*
  • Rats


  • Lipids
  • Oligosaccharides
  • Polysaccharides
  • fructooligosaccharide
  • maltodextrin