Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study

Int Urol Nephrol. 2018 Nov;50(11):1975-1980. doi: 10.1007/s11255-018-1975-x. Epub 2018 Aug 28.


Purpose: To compare serum level of vitamin D [25(OH)D] in patients with life-long premature ejaculation (LPE) versus healthy controls.

Methods: Healthy married potent males were recruited from February 2017 to January 2018. Group A included 40 patients suffering from LPE who were compared versus 40 healthy controls (Group B). Participants suffering from hormonal disorders, obesity, neurological, psychological, or chronic diseases or taking medications that may affect ejaculatory function, serum level of vitamin D, or the accuracy of intra-vaginal ejaculation latency time (IELT) were excluded. LPE was self-reported by the patients with subsequent feelings of frustration and measured by premature ejaculation diagnostic tool (PEDT) and IELT using stopwatch handled by their partners. 25(OH)D was measured by obtaining 2 ml of venous blood. Statistical analysis was performed using Student t, Mann-Whitney, Chi square tests, logistic regression analysis, and Spearman correlation.

Results: Sixteen (20%) participants had vitamin D insufficiency/deficiency. All of them were in PE group. 25(OH)D correlated significantly with IELT (r2 = 0.349; p < 0.001) and PEDT (r2 = 0.425; p < 0.001). There was no statistically significant difference in age (p = 0.341), BMI (p = 1) or IIEF-5 (p = 0.408) in both groups. 25(OH)D was significantly lower in patients than controls (35.75 vs. 58.92 ng/ml, p < 0.001). ROC analysis revealed that the best cut-off value of 25(OH)D to detect patients suffering from LPE was 50.65 ng/ml with a sensitivity and specificity of 85% for both. 25(OH)D remained a significant risk factor for LPE in the logistic regression analysis (p < 0.001).

Conclusions: The current study showed that vitamin D has significant association with LPE and correlates significantly with IELT and PEDT.

Keywords: Lifelong premature ejaculation; Serotonin; Serum vitamin D; Tryptophan hydroxylase; Vitamin D deficiency.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Case-Control Studies
  • Humans
  • Male
  • Premature Ejaculation / blood*
  • Premature Ejaculation / etiology*
  • Risk Factors
  • Sensitivity and Specificity
  • Vitamin D / blood*
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / diagnosis
  • Vitamin D Deficiency / epidemiology*
  • Young Adult


  • Vitamin D