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Review
. 2018 Dec;61(14):1024-1035.
doi: 10.1002/jlcr.3680. Epub 2018 Oct 11.

New Radical Methods for the Potential Synthesis of carbon-13 and carbon-14 Labeled Complex Products

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Review

New Radical Methods for the Potential Synthesis of carbon-13 and carbon-14 Labeled Complex Products

Brad D Maxwell. J Labelled Comp Radiopharm. .

Abstract

The isotopic labeling of molecules for agrichemical and pharmaceutical uses is becoming more challenging as molecules become larger, involve more stereochemistry, and as intellectual property rights become more complex. As such, isotope chemists need to continually add new isotopic methods to their armamentarium to successfully label complex molecules with carbon-13 and carbon-14. Recently, there has been a surge in the use of radicals to form new carbon-carbon bonds and for the incorporation of functional groups which can be used to incorporate isotopically labeled carbons. This review will describe some potential new radical methods for incorporating isotopically labeled carbon into complex molecules or into substrates that can be attached to late stage intermediates to generate labeled products.

Keywords: carbon-13; carbon-14; complex molecules; late-stage isotopic labeling; radical chemistry.

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