What do GABA neurons really do? They make possible variability generation in relation to demand

Exp Neurol. 1986 Aug;93(2):279-90. doi: 10.1016/0014-4886(86)90189-5.

Abstract

It is proposed that GABA neurons play key roles in maintaining meaningful communications within and among neural units by making possible variability generation in relation to demand. Activities of GABAergic inhibitory projection neurons from command centers and local circuit GABAergic inhibitory interneurons allow adaptive nervous system function to take place in a manner characterized by freedom without license. Through their multiple activities and connections these neurons make possible smooth transitions between modes of nervous system function over a range of increasing demands (neural pressures), enabling organisms to explore full ranges of their options.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / physiology
  • Humans
  • Interneurons / physiology
  • Models, Neurological
  • Neural Inhibition
  • Neural Pathways / physiology
  • Neurology / trends
  • Neurons / physiology*
  • Synaptic Transmission
  • Time Factors
  • gamma-Aminobutyric Acid / physiology*

Substances

  • gamma-Aminobutyric Acid