Vitamin D in SLE: a role in pathogenesis and fatigue? A review of the literature

Lupus. 2018 Nov;27(13):2003-2011. doi: 10.1177/0961203318796293. Epub 2018 Aug 29.


Fatigue is a common, disabling problem that is highly prevalent in patients with systemic lupus erythematous (SLE). More recently, vitamin D status has been established as a potential contributor to SLE pathogenesis and manifestations, in particular fatigue. This review summarizes the literature regarding the role of vitamin D in SLE, and provides an overview of the recent literature examining the association between vitamin D and fatigue in patients with SLE. Finally, the role of vitamin D supplementation in the treatment of SLE-related fatigue is considered.

Keywords: Systemic lupus erythematosus; fatigue; vitamin D.

Publication types

  • Review

MeSH terms

  • Dietary Supplements
  • Fatigue / drug therapy
  • Fatigue / etiology*
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Randomized Controlled Trials as Topic
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome
  • Vitamin D / physiology*
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / drug therapy


  • Vitamin D