Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy

Int J Mol Sci. 2018 Aug 29;19(9):2565. doi: 10.3390/ijms19092565.

Abstract

Recent evidence suggests that myeloid cells are critical in cancer development and therapy resistance processes. Pharmacological targeting of tumor-associated myeloid cells is an emerging approach among upcoming immune therapies. Surprisingly, myeloid cells are heterogeneous, including a subset of the myeloid cell displaying angiogenic properties in solid tumors. There is an urgent need to delineate angiogenic myeloid cell populations in order to facilitate specific targeting of protumor myeloid cells among heterogeneous pool. This review article is intended to compile all the relevant information in the literature for improved understanding of angiogenic myeloid cells and their role in tumor refractoriness to cancer therapy.

Keywords: MDSC; angiogenic; antiangiogenic; chemotherapy; immunotherapy; myeloid; radiotherapy; tumor.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD / metabolism
  • Cadherins / metabolism
  • Humans
  • Immunotherapy
  • Myeloid Cells / cytology*
  • Myeloid Cells / physiology*
  • Neoplasms / radiotherapy*
  • Neoplasms / therapy*
  • Platelet Endothelial Cell Adhesion Molecule-1 / metabolism
  • Receptor, TIE-2 / metabolism
  • Vascular Endothelial Growth Factor A / metabolism
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism

Substances

  • Antigens, CD
  • Cadherins
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Vascular Endothelial Growth Factor A
  • cadherin 5
  • Receptor, TIE-2
  • Vascular Endothelial Growth Factor Receptor-2