The nucleotide sequence of three genes participating in the adipose differentiation of 3T3 cells

J Biol Chem. 1986 Aug 15;261(23):10821-7.


When 3T3 cells undergo adipose differentiation, they are reprogrammed by changes in gene expression of sufficient magnitude to greatly alter the protein composition of the cells. Three participating genes encode glycerophosphate dehydrogenase, a lipid-binding protein, and a serine protease. These three genes have now been cloned and sequenced. Their exon/intron structures are described, together with some interesting peculiarities and some regions of common sequence. It remains to be demonstrated whether the information for common participation of the genes in the program of differentiation resides in controlling elements within the regions sequenced.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adipose Tissue / cytology*
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Carrier Proteins / genetics
  • Cell Differentiation*
  • Cells, Cultured
  • Cloning, Molecular
  • DNA / analysis
  • DNA Restriction Enzymes
  • Endopeptidases / genetics
  • Genes*
  • Glycerolphosphate Dehydrogenase / genetics
  • Lipids / genetics
  • Mice
  • Serine Endopeptidases


  • Carrier Proteins
  • Lipids
  • DNA
  • Glycerolphosphate Dehydrogenase
  • DNA Restriction Enzymes
  • Endopeptidases
  • Serine Endopeptidases

Associated data

  • GENBANK/M13366
  • GENBANK/M13385
  • GENBANK/M13386