Cyclic Vomiting Syndrome in Children and Adults: What Is New in 2018?

Curr Gastroenterol Rep. 2018 Aug 29;20(10):46. doi: 10.1007/s11894-018-0654-5.


Purpose of review: Cyclic vomiting syndrome (CVS) is a disabling functional gastrointestinal disorder characterized by severe vomiting episodes that alternate with symptom-free periods. The purpose of this review is to summarize current knowledge and highlight most recent data on prevalence, diagnosis, management, and impact of CVS in children and adults.

Recent findings: Originally thought to be a pediatric disorder, the past decade has witnessed a considerable increase in CVS diagnosed in adults. Despite improved recognition of CVS, without a delineated pathophysiology and specific biomarker, it remains classified as a functional gastrointestinal disorder. Migraines and CVS share a common pathway based on several studies and response to migraine therapy. Recent work has begun to expand the list of comorbidities and identify plausible mechanisms and new therapeutic avenues. This review seeks to highlight best practices and novel therapies for CVS based on expert consensus and review of available literature.

Keywords: Cannabinoid hyperemesis syndrome; Cyclic vomiting syndrome; Functional nausea and vomiting disorders.

Publication types

  • Review

MeSH terms

  • Adult
  • Child
  • Cost of Illness
  • Gastrointestinal Diseases* / diagnosis
  • Gastrointestinal Diseases* / epidemiology
  • Gastrointestinal Diseases* / etiology
  • Gastrointestinal Diseases* / therapy
  • Humans
  • Vomiting* / diagnosis
  • Vomiting* / epidemiology
  • Vomiting* / etiology
  • Vomiting* / therapy

Supplementary concepts

  • Familial cyclic vomiting syndrome