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Review
. 2019 Feb;23(1):215-259.
doi: 10.1007/s11030-018-9870-z. Epub 2018 Aug 30.

Synthetic Applications and Methodology Development of Chan-Lam Coupling: A Review

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Review

Synthetic Applications and Methodology Development of Chan-Lam Coupling: A Review

Iqra Munir et al. Mol Divers. .

Abstract

Chan-Lam coupling is one of the most popular and easy methods to perform arylation of amines (N-arylations). This cross-coupling is generally performed by reacting aryl boronate derivatives with a variety of substrates involving nitrogen containing functional groups such as amines, amides, ureas, hydrazine, carbamates. This article summarizes the synthetic applications of this reaction and the efforts of scientists to develop novel and efficient methodologies for this reaction.

Keywords: Boronic acids; Chan–Lam coupling; Cross-coupling reactions; N-Arylation; N-heterocycles.

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