Infectious Mononucleosis and Lyme Disease as Confounding Diagnoses: A Report of 2 Cases

Clin Med Res. 2018 Dec;16(3-4):66-68. doi: 10.3121/cmr.2018.1419. Epub 2018 Aug 30.


Lyme disease and infectious mononucleosis are common illnesses that share similar clinical presentations. Significant cross-reactivity is known to occur between Lyme and EBV serologic assays complicating the diagnosis. To date, no prior cases of concurrent acute Lyme and EBV infections have been reported. We describe the clinical presentation of two children with confirmed early Lyme disease and features suggestive of infectious mononucleosis, including one case of probable Lyme and EBV co-infection.

Keywords: Borrelia burgdorferi; Co-infection; Epstein-Barr virus; Infectious mononucleosis; Lyme disease.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Child, Preschool
  • Humans
  • Infectious Mononucleosis / diagnosis*
  • Infectious Mononucleosis / immunology
  • Lyme Disease / diagnosis*
  • Lyme Disease / immunology
  • Male