Host genetic control of mosquito-borne Flavivirus infections

Mamm Genome. 2018 Aug;29(7-8):384-407. doi: 10.1007/s00335-018-9775-2. Epub 2018 Aug 25.


Flaviviruses are arthropod-borne viruses, several of which represent emerging or re-emerging pathogens responsible for widespread infections with consequences ranging from asymptomatic seroconversion to severe clinical diseases and congenital developmental deficits. This variability is due to multiple factors including host genetic determinants, the role of which has been investigated in mouse models and human genetic studies. In this review, we provide an overview of the host genes and variants which modify susceptibility or resistance to major mosquito-borne flaviviruses infections in mice and humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers
  • Culicidae / virology*
  • Disease Models, Animal
  • Disease Susceptibility
  • Flavivirus / physiology*
  • Flavivirus Infections / genetics*
  • Flavivirus Infections / immunology
  • Flavivirus Infections / transmission
  • Flavivirus Infections / virology*
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Host-Pathogen Interactions / genetics*
  • Host-Pathogen Interactions / immunology
  • Humans
  • Mice


  • Biomarkers