Advanced imaging in pulmonary hypertension: emerging techniques and applications

Int J Cardiovasc Imaging. 2019 Aug;35(8):1407-1420. doi: 10.1007/s10554-018-1448-4. Epub 2018 Aug 30.

Abstract

Pulmonary hypertension (PH) is a pathophysiological disorder defined by an increase in pulmonary arterial pressure which can occur in multiple clinical conditions. Irrespective of etiology, PH entails a negative impact on exercise capacity and quality of life, and is associated with high mortality particularly in pulmonary arterial hypertension. Noninvasive imaging techniques play an important role in suggesting the presence of PH, providing noninvasive pulmonary pressure measurements, classifying the group of PH, identifying a possibly underlying disease, providing prognostic information and assessing response to treatment. While echocardiography, computed tomography (CT) and ventilation/perfusion scans are an integral part of routine work-up of patients with suspected PH according to current guidelines and across centers, innovative new techniques and applications in the field of PH such as 3D echocardiography, dual-energy CT, 4D flow magnetic resonance imaging (MRI), T1 and extracellular volume fraction mapping, non-contrast-enhanced MRI sequences for perfusion and ventilation assessment, and molecular-targeted positron emission tomography are emerging. This review discusses advanced and emerging imaging techniques in diagnosis, prognostic evaluation and follow-up of patients with PH.

Keywords: Imaging; Pulmonary circulation; Pulmonary hypertension.

Publication types

  • Review

MeSH terms

  • Computed Tomography Angiography / methods
  • Diagnostic Imaging / methods*
  • Echocardiography / methods
  • Hemodynamics*
  • Humans
  • Hypertension, Pulmonary / diagnostic imaging*
  • Hypertension, Pulmonary / physiopathology
  • Hypertension, Pulmonary / therapy
  • Magnetic Resonance Imaging / methods
  • Perfusion Imaging / methods
  • Positron-Emission Tomography / methods
  • Predictive Value of Tests
  • Prognosis
  • Pulmonary Artery / diagnostic imaging*
  • Pulmonary Artery / physiopathology
  • Pulmonary Circulation*
  • Reproducibility of Results