Chronic inflammatory demyelinating polyneuropathy of infancy: a corticosteroid-responsive disorder

Ann Neurol. 1986 Jul;20(1):76-81. doi: 10.1002/ana.410200113.

Abstract

We present the clinical, electrophysiological, and histopathological findings in 6 children with early-onset chronic inflammatory demyelinating neuropathy. The clinical features initially suggested a genetically determined disorder in each patient. Sural nerve biopsy showed changes of chronic demyelination with multifocal endoneurial edema and mononuclear cellular infiltrates. All children improved with corticosteroid therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child, Preschool
  • Demyelinating Diseases / diagnosis*
  • Demyelinating Diseases / drug therapy
  • Demyelinating Diseases / pathology
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Neural Conduction
  • Peripheral Nerves / pathology
  • Peripheral Nervous System Diseases / diagnosis*
  • Prednisone / therapeutic use*

Substances

  • Prednisone