Predictive factors of weaning from mechanical ventilation and extubation outcome: A systematic review

J Crit Care. 2018 Dec:48:56-62. doi: 10.1016/j.jcrc.2018.08.023. Epub 2018 Aug 20.


Purpose: To identify, describe and discuss the parameters used to predict weaning from mechanical ventilation and extubation outcomes.

Methods: Systematic review of scientific articles using four electronic databases: PubMed, Embase, PEDro and Cochrane Library. Search terms included "weaning", "extubation", "withdrawal" and "discontinuation", combined with "mechanical ventilation" and "predictive factors", "predictive parameters" and "predictors for success". In this study, we included original articles that presented predictive factors for weaning or extubation outcomes in adult patients and not restricted to a single disease. Articles not written in English were excluded.

Results: A total of 43 articles were included, with a total of 7929 patients and 56 different parameters related to weaning and extubation outcomes. Rapid Shallow Breathing Index (RSBI) was the most common predictor, discussed in 15 studies (2159 patients), followed by Age and Maximum Inspiratory Pressure in seven studies. The other 53 parameters were found in less than six studies.

Conclusion: There are several parameters used to predict weaning and extubation outcomes. RSBI was the most frequently studied and seems to be an important measurement tool in deciding whether to wean/extubate a patient. Furthermore, the results demonstrated that weaning and extubation should be guided by several parameters, and not only to respiratory ones.

Keywords: Extubation; Mechanical ventilation; Predictive parameters, outcome; Weaning.

Publication types

  • Systematic Review

MeSH terms

  • Airway Extubation / methods*
  • Critical Illness / therapy*
  • Humans
  • Predictive Value of Tests
  • Respiration, Artificial / instrumentation*
  • Respiratory Function Tests
  • Ventilator Weaning / methods*