Fish intake and risk of mortality due to aortic dissection and aneurysm: A pooled analysis of the Japan cohort consortium

Clin Nutr. 2019 Aug;38(4):1678-1683. doi: 10.1016/j.clnu.2018.08.007. Epub 2018 Aug 16.


Background & aims: Many studies have suggested that fish intake is associated with protection from risk of atherosclerotic diseases; however, this association with aortic diseases has not been elucidated worldwide. We hypothesized that fish intake is inversely associated with mortality from aortic diseases (aortic dissection and aneurysm).

Methods: The study was conducted as a pooled analysis of original data from a maximum of 8 cohort studies, comprising a total of 366,048 community-based men and women who had no history of cardiovascular disease or cancer. In each cohort, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality from aortic dissection, aneurysm and total aortic disease according to the frequency of fish intake and estimated summary HRs derived from each study.

Results: Nonlinear inverse associations were found between fish intake and total aortic disease. Compared with persons who ate fish 1-2 times/week, persons who seldom ate fish had higher mortality from total aortic disease (multivariable-adjusted pooled HR = 1.93; 95% CI, 1.13-3.31). Higher mortality was not seen in those who ate fish 1-2 times/month. A similar pattern was observed for aortic dissection. Regarding aortic aneurysm, both persons who seldom ate fish and those who ate fish 1-2 times/month had higher mortality (HR = 1.99; 95% CI, 0.90-4.40 and HR = 1.86; 95% CI, 0.87-3.98, respectively).

Conclusions: Persons who seldom ate fish had higher mortality from aortic dissection, aneurysm, and total aortic diseases.

Keywords: Diet; Epidemiology; Fatty acids; Meta-analysis; Prospective cohort study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Aortic Aneurysm / mortality*
  • Aortic Dissection / mortality*
  • Diet* / mortality
  • Diet* / statistics & numerical data
  • Female
  • Fishes
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Prospective Studies
  • Seafood / statistics & numerical data*