Abstract
Protopine, cryptopine and allocryptopine were demonstrated to enhance 3H-gamma-aminobutyric acid (3H-GABA) binding to rat brain synaptic membrane receptors. The above finding might be indicative of benzodiazepine-like activity of these alkaloids.
MeSH terms
-
Alkaloids / pharmacology*
-
Animals
-
Benzophenanthridines
-
Berberine Alkaloids*
-
Diazepam / pharmacology
-
In Vitro Techniques
-
Male
-
Rats
-
Rats, Inbred Strains
-
Receptors, GABA-A / drug effects*
-
Synaptic Membranes / drug effects
Substances
-
Alkaloids
-
Benzophenanthridines
-
Berberine Alkaloids
-
Receptors, GABA-A
-
Diazepam
-
protopine