Heterologous protection elicited by a live, attenuated, Leptospira vaccine

doi:10.1016/j.vetmic.2018.07.018

. 2018 Sep:223:47-50.

doi: 10.1016/j.vetmic.2018.07.018. Epub 2018 Jul 21.

Heterologous protection elicited by a live, attenuated, Leptospira vaccine

Gerald L Murray¹, Theeraya Simawaranon², Chamraj Kaewraemruaen³, Ben Adler¹, Rasana W Sermswan⁴

Affiliations

¹ Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
² Melioidosis Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
³ Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
⁴ Melioidosis Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address: rasana@kku.ac.th.

PMID: 30173751
DOI: 10.1016/j.vetmic.2018.07.018

Heterologous protection elicited by a live, attenuated, Leptospira vaccine

Gerald L Murray et al. Vet Microbiol. 2018 Sep.

. 2018 Sep:223:47-50.

doi: 10.1016/j.vetmic.2018.07.018. Epub 2018 Jul 21.

Authors

Gerald L Murray¹, Theeraya Simawaranon², Chamraj Kaewraemruaen³, Ben Adler¹, Rasana W Sermswan⁴

Affiliations

¹ Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
² Melioidosis Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
³ Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
⁴ Melioidosis Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address: rasana@kku.ac.th.

PMID: 30173751
DOI: 10.1016/j.vetmic.2018.07.018

Abstract

A previously-described live, attenuated vaccine (M1352, serovar Manilae, serogroup Pyrogenes) was tested in the hamster model of infection for cross-protective immunity. The vaccine elicited strong, significant cross-protection against lethal infection by strains representing four serologically distinct leptospiral serovars (Grippotyphosa, Australis, Canicola, and Autumnalis). Combined with our previously reported protection against serovars Pomona and Manilae, this work demonstrates unequivocal proof of concept for cross-protective immunity in leptospirosis.

Keywords: Cross-protection; Leptospirosis; Live vaccine; Serovar.

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Heterologous protection elicited by a live, attenuated, Leptospira vaccine

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Heterologous protection elicited by a live, attenuated, Leptospira vaccine

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