Expression of epidermal growth factor receptor (EGF-R) in human lung tumours

Br J Cancer. 1986 Aug;54(2):265-9. doi: 10.1038/bjc.1986.172.

Abstract

Epidermal growth factor receptor (EGF-R) expression was assessed in 63 lung tumour samples with a monoclonal antibody (EGF-R1) by indirect immunoperoxidase staining on cryostat sections. All 15 small cell lung cancer samples were negative whereas over 80% of the 48 non small lung cancer stained positively. In 30 bronchial biopsies two monoclonal antibodies against the cytoplasmic part of the EGF-R were evaluated. These antibodies showed weaker staining than EGF-R1. No additional or enhanced staining as compared with EGF-R1 was observed, suggesting a lack of enhanced expression of a truncated EGF-R analogous to the v-erb-B oncogene product. Monoclonal antibodies against the EGF-R may be helpful diagnostically in differentiating small cell from non small cell lung cancer and may also be important in elucidating biological differences in primary lung cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / analysis
  • Antibodies, Monoclonal
  • Carcinoma, Small Cell / analysis
  • Carcinoma, Squamous Cell / analysis
  • Epidermal Growth Factor / analysis*
  • ErbB Receptors
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Lung Neoplasms / analysis*
  • Male
  • Middle Aged
  • Receptors, Cell Surface / analysis*

Substances

  • Antibodies, Monoclonal
  • Receptors, Cell Surface
  • Epidermal Growth Factor
  • ErbB Receptors