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The Renin Angiotensin System in Liver and Lung: Impact and Therapeutic Potential in Organ Fibrosis

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The Renin Angiotensin System in Liver and Lung: Impact and Therapeutic Potential in Organ Fibrosis

Amal Abdul-Hafez et al. J Lung Pulm Respir Res.

Abstract

Liver and lung fibrosis are two main organ diseases that are of particular importance in both Egypt and the US. Hepatitis C Virus "HCV" infection and idiopathic pulmonary fibrosis (IPF) are fibrotic diseases of the liver and lung respectively. The liver and lung are reported in literature to share many immune/inflammatory responses to damage through the lung-liver axis. Most importantly, HCV was shown to enhance the development of IPF and is considered one of the risk factors for IPF. The renin angiotensin system (RAS) plays a critical role in the fibrogenesis and inflammation damage of many organs including liver and lung. The relatively recently identified component of RAS, angiotensin converting enzyme-2 (ACE-2), has shown a promising therapeutic potential in models of liver and pulmonary fibrosis. This article reviews the role of RAS in organ fibrosis with focus on role of ACE-2 in fibrotic diseases of the liver and the lung.

Keywords: angiotensin peptide; bronchopulmonary dysplasia; hepatitis C virus; idiopathic pulmonary fibrosis; lung-liver axis; renin angiotensin system.

Conflict of interest statement

Conflict of interest The authors do not have any conflict of interests.

Figures

Figure 1
Figure 1
Renin Angiotensin System (RAS).

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