The renin angiotensin system in liver and lung: impact and therapeutic potential in organ fibrosis

J Lung Pulm Respir Res. 2018;5(1):00160. Epub 2018 Feb 27.


Liver and lung fibrosis are two main organ diseases that are of particular importance in both Egypt and the US. Hepatitis C Virus "HCV" infection and idiopathic pulmonary fibrosis (IPF) are fibrotic diseases of the liver and lung respectively. The liver and lung are reported in literature to share many immune/inflammatory responses to damage through the lung-liver axis. Most importantly, HCV was shown to enhance the development of IPF and is considered one of the risk factors for IPF. The renin angiotensin system (RAS) plays a critical role in the fibrogenesis and inflammation damage of many organs including liver and lung. The relatively recently identified component of RAS, angiotensin converting enzyme-2 (ACE-2), has shown a promising therapeutic potential in models of liver and pulmonary fibrosis. This article reviews the role of RAS in organ fibrosis with focus on role of ACE-2 in fibrotic diseases of the liver and the lung.

Keywords: angiotensin peptide; bronchopulmonary dysplasia; hepatitis C virus; idiopathic pulmonary fibrosis; lung-liver axis; renin angiotensin system.