[Correlation between nasopharyngeal carcinoma (NPC) and HLA in Hunan Province]

Zhonghua Zhong Liu Za Zhi. 1986 May;8(3):170-2.
[Article in Chinese]

Abstract

24 patients with NPC and 49 normal individuals in Hunan Province were typed for their HLA-A and -B antigens. The results showed that the antigen frequencies of HLA-A1 and HLA-Bw63 were significantly higher in NPC patient group than in the normal group (P = 0.0098 and P = 0.0028, respectively) and the antigen frequency of HLA-A11 was significantly lower in NPC patient group than in the normal group (P = 0.0075). In addition, the joint occurrence of A2 and B17 was increased in NPC patient group (P = 0.0350). The results suggested that HLA-A1 be a regional antigen associated with NPC in Hunan or Southern China, and that HLA-Bw63 be a new kind of antigen associated with NPC.

Publication types

  • English Abstract

MeSH terms

  • China
  • HLA Antigens / analysis*
  • HLA-A1 Antigen
  • HLA-A2 Antigen
  • HLA-B Antigens*
  • Herpesvirus 4, Human / immunology
  • Humans
  • Nasopharyngeal Neoplasms / immunology*

Substances

  • HLA Antigens
  • HLA-A1 Antigen
  • HLA-A2 Antigen
  • HLA-B Antigens
  • HLA-B17 antigen
  • HLA-B63 antigen