Objective: Introduction: According to official statistics, the incidence of coronary artery disease in the working-age population in 2015 is registered in 9.7 per 100 thousand of the population; a significant number of the patients with IHD are the elderly, although there is also a "rejuvenation" of this pathology. Ischemic heart disease tends to occupy a top position amongst the causes of temporary and permanent disability, leading to the complete disability of the population. Numerous clinical and laboratory studies revealed a direct interconnection between the severity of the course of generalized periodontitis and the functional class of stable angina pectoris. The aim of my study was to determine effective comprehensive treatment for the patient with chronical generalized paradontitis, associated with ischemic heart disease.
Patients and methods: Materials and methods: The examination and treatment of 42 subjects with chronic generalized periodontitis I-II grade at the age from 45 to 60 years, who suffered from coronary heart disease, with a mean duration of 1.5 to 5 years, was performed.Clinical studies have revealed that in the patients, suffering from coronary artery disease, during the period of in-patient treatment, predominantly generalized periodontitis takes place at the stage of exacerbation (89.5%).
Results: Results and conclusions: Exacerbation of HGP I and II in the patients, suffering from stable angina pectoris, is accompanied by significant disorders of metabolic processes; changes of the condition of regional hemodynamics and microcirculation in periodontal tissues, which is proven by alteration in reopardotography rates. It is confirmed that while the administration of antihypoxic therapy in the comprehensive treatment of patients with CGP, suffering from coronary heart disease, it is advisable to take into account the sequence of violations of bioenergetic processes that begin on the substrate region of the respiratory chain with a violation of the ICFA I and extend with the increase of oxygen insufficiency to the terminal cytochrome oxidase site. On the basis of this, the protection of the body from oxygen deficiency with the help of antihypoxic drugs provides, as a mandatory condition, the restoration of the energy-absorbing function. The administration, as part of integrated therapy, of local antihypoxic and coenzyme Q10 in patients with coronary heart disease is accompanied by a significant improvement in the clinical manifestation of subjective and objective characteristics; positive dynamics of periodontal indicators; correction of antioxidant and nitroxydergic systems, which manifested in increasing of the antioxidant potential in the oral liquid as well as optimization of processes of regional hemodynamics and microcirculation.
Keywords: generalized parodontitis; ischemic heart disease; CoQ10; antihypoxic drugs.