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. 2018 Sep 3;18(1):865.
doi: 10.1186/s12885-018-4780-0.

Prognostic value of differentiation status in gastric cancer

Fan Feng  1 , Jinqiang Liu  1   2 , Fei Wang  1   3 , Gaozan Zheng  1 , Qiao Wang  1   4 , Shushang Liu  1 , Guanghui Xu  1 , Man Guo  1 , Xiao Lian  1 , Hongwei Zhang  5
Affiliations
Free PMC article

Prognostic value of differentiation status in gastric cancer

Fan Feng et al. BMC Cancer. .
Free PMC article

Abstract

Background: Up to date, investigation of the prognostic value of differentiation status mainly focused on signet ring cell and mucinous gastric cancer. Thus, the present study aims to investigate the clinicopathological features and prognosis of gastric cancer patients with well, moderately and poorly differentiation status.

Methods: From September 2008 to March 2015, a total of 3090 gastric cancer patients treated with radical D2 gastrectomy were enrolled in the present study. Clinicopathological characteristics and prognosis of gastric cancer patients with well, moderately and poorly differentiation status were analyzed.

Results: There were 2422 male (78.4%) and 668 female (21.6%). The median age was 58 (20-90) years. There were 370 (12.0%) well differentiated tumors, 836 (27.0%) moderately differentiated tumors and 1884 (61.0%) poorly differentiated tumors. Well and moderately differentiation status were associated with older age, male gender, smaller tumor, shallower invasion, less lymph node involvement and earlier tumor stage (all p < 0.001). Inversely, poorly differentiation status was associated with younger age, female gender, larger tumor, deeper invasion, more lymph node involvement and later tumor stage (all p < 0.001). With respect to prognosis, well differentiation status was associated with favorable overall survival and poorly differentiation status was associated with unfavorable overall survival (p < 0.001). However, after matching with age, tumor size, T and N stage, there was no significant difference among the overall survival of the three groups (p = 0.415).

Conclusions: Well, moderately and poorly differentiation status was significantly associated with clinicopathological features of gastric cancer patients. However, it was not associated with the prognosis of gastric cancer patients.

Keywords: Clinicopathological characteristics; Differentiation status; Gastric cancer; Prognosis.

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Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the Ethics Committee of Xijing Hospital, and written informed consent was obtained from the patients in our center.

Consent for publication

Not applicable.

Competing interests

All of the authors declare that there are no financial or other relations that could lead to a conflict of interest.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Overall survival of patients with different differentiation status
Fig. 2
Fig. 2
Overall survival of patients with different differentiation status after match
See this image and copyright information in PMC

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