High-resolution FLAIR MRI at 7 Tesla for treatment planning in glioblastoma patients

Sebastian Regnery; Benjamin R Knowles; Daniel Paech; Nicolas Behl; Jan-Eric Meissner; Paul Windisch; Semi Ben Harrabi; Denise Bernhardt; Heinz-Peter Schlemmer; Mark E Ladd; Stefan Rieken; Jürgen Debus; Sebastian Adeberg

doi:10.1016/j.radonc.2018.08.002

High-resolution FLAIR MRI at 7 Tesla for treatment planning in glioblastoma patients

Radiother Oncol. 2019 Jan:130:180-184. doi: 10.1016/j.radonc.2018.08.002. Epub 2018 Aug 31.

Affiliations

¹ Department of Radiation Oncology, Heidelberg University Hospital, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
² Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
³ Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Department of Radiation Oncology, Heidelberg University Hospital, Germany.
⁵ Department of Radiation Oncology, Heidelberg University Hospital, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany.
⁶ Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Physics and Astronomy and Faculty of Medicine, University of Heidelberg, Germany.
⁷ Department of Radiation Oncology, Heidelberg University Hospital, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany. Electronic address: sebastian.adeberg@med.uni-heidelberg.de.

PMID: 30177373
DOI: 10.1016/j.radonc.2018.08.002

Abstract

Ultra-high field MRI is an emerging technique promising high-resolution images for radiotherapy planning. We compared a 7 Tesla FLAIR sequence with clinical FLAIR imaging at 3 Tesla in glioblastoma patients before radiotherapy. High-resolution 7 Tesla FLAIR imaging may enhance the depiction of organs at risk and possibly modify target volumes.

Keywords: Glioblastoma; MR-guided radiotherapy; Ultra-High-Field MRI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Brain Neoplasms / diagnostic imaging
Brain Neoplasms / radiotherapy
Female
Glioblastoma / diagnostic imaging
Glioblastoma / radiotherapy*
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Radiotherapy Planning, Computer-Assisted / methods*