The comings and goings of PARP-1 in response to DNA damage

DNA Repair (Amst). 2018 Nov;71:177-182. doi: 10.1016/j.dnarep.2018.08.022. Epub 2018 Aug 23.

Abstract

Poly(ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA damage response, acting as a first responder that detects DNA strand breaks, and contributes to repair pathway choice and the efficiency of repair through modulation of chromatin structure and through interaction with and modification of a multitude of DNA repair factors. This perspective summarizes our knowledge of PARP-1 involvement in DNA repair pathways, and highlights recent structural and functional data regarding the activation of PARP-1 upon detecting DNA damage, and the release and trapping of PARP-1 at sites of DNA damage.

Keywords: DNA damage response; PARP; Poly(ADP-ribose).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA / metabolism
  • DNA Breaks*
  • DNA Repair*
  • Humans
  • Poly (ADP-Ribose) Polymerase-1 / metabolism*
  • Signal Transduction

Substances

  • DNA
  • PARP1 protein, human
  • Poly (ADP-Ribose) Polymerase-1