Activation of a D-form of rabbit muscle glycogen synthase by Ca2+-activated protease

FEBS Lett. 1986 Sep 1;205(1):1-5. doi: 10.1016/0014-5793(86)80853-5.


Glycogen synthase isolated from rabbit skeletal muscle as a D-form (synthase D2) is activated by a rat liver cytosolic protein differing from any of the known protein phosphatases (D2 activase). Although reversible by phosphorylation by cyclic AMP-dependent protein kinase, the activation is a result of limited proteolysis by D2 activase, which has been identified as the Ca2+-activated protease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calpain / metabolism*
  • Cytosol / enzymology
  • Enzyme Activation
  • Glycogen Synthase / metabolism*
  • Liver / enzymology
  • Muscles / enzymology*
  • Phosphorylation
  • Rabbits
  • Rats


  • Glycogen Synthase
  • Calpain